The concomitant utilization of opioids with other medication that influence the serotonergic neurotransmitter program has resulted in serotonin syndrome.

Remedy of overdosage is actually symptomatic and supportive. Only in instances of maximum overdosage or person sensitivity do critical signs, including respiration, pulse, hypertension, temperature, and EKG, should be monitored. Activated charcoal orally or by lavage might be provided, or sodium or magnesium sulfate orally being a cathartic. Awareness needs to be provided into the reestablishment of sufficient respiratory exchange by provision of a patent airway and institution of assisted or managed air flow. Diazepam can be applied to manage convulsions. Acidosis and electrolyte losses must be corrected. Be aware that any depressant effects of promethazine HCl usually are not reversed by naloxone.

Your Health care provider may possibly do blood tests to look for adrenal gland difficulties. Call your Health care supplier at once if you have any of those signs or symptoms:

Therapy adjunctive to meperidine or other analgesics for Charge of postoperative agony. Sedation in each youngsters and Older people, together with reduction of apprehension and creation of light snooze from which the individual might be very easily aroused.

Clinical studies of promethazine formulations didn't include things like adequate quantities of topics aged sixty five and over to find out whether they reply in a different way from young topics. Other documented clinical working experience has not identified variances in responses in between the elderly and more youthful patients.

There is not any general settlement about specific pharmacological treatment regimens for uncomplicated NMS.

The precise system of action of codeine along with other opiates isn't identified; nevertheless, codeine is considered to act centrally within the cough Middle. In excessive read more doses, codeine will depress respiration.

Phenothiazines are affiliated with dystonic reactions, notably in pediatric people that have an acute health issues connected with dehydration. Paradoxical reactions, together with dystonia, torticollis, tongue protrusion, hyperexcitability, and abnormal movements are already claimed in individuals adhering to only one administration of promethazine. Discontinue Promethazine HCl and Codeine Phosphate Oral Answer if a paradoxical reaction happens.

Caution needs to be exercised when administering Promethazine to pediatric individuals two years of age and older. It is recommended that the lowest powerful dose of Promethazine be Utilized in pediatric clients two decades of age and more mature and concomitant administration of other drugs with respiratory depressant effects be avoided.

Asthma Along with other Respiratory Ailments: Narcotic analgesics or cough suppressants, like codeine, shouldn't be used in asthmatic clients (see CONTRAINDICATIONS). Nor ought to they be Utilized in acute febrile disease linked to productive cough or in Persistent respiratory disorder where interference with power to obvious the tracheobronchial tree of secretions might have a deleterious effect on the client’s respiratory functionality.

Serious breathing difficulties. Promethazine HCl Oral Resolution shouldn't be Utilized in clients with weak lung function like Persistent obstructive lung condition or respiration troubles even though sleeping (snooze apnea.)

Neuroleptic malignant syndrome (NMS) which may result in Demise. Let you know healthcare service provider at once When you've got any of the next indicators of NMS:

Stimulation could possibly be evident, especially in small children and geriatric clients. Convulsions could seldom occur. A paradoxical response is claimed in little ones getting one doses of 75 mg to 125 mg orally, characterised by hyperexcitability and nightmares.

Promethazine Symptoms and indicators of overdosage with promethazine vary from mild despair with the central nervous method and cardiovascular system to profound hypotension, respiratory despair, unconsciousness and sudden death.